1 year post-doctoral position available starting summer 2008 (Paris, France)

You are an organic chemist with a reasonable knowledge of NMR spectroscopy?
Become involved in the development of a completely new NMR method for untangling the most complex biological architectures!

Research center information
This post-doctoral position (attractive salary) is available within the French Atomic Energy Commission (CEA) located near Paris (Saclay). Our center is recognized as a centre of excellence in physics, chemistry, biophysics, biology and biochemistry (6000 workers…). Our chemistry group consists of 15 permanent researchers, 6 technicians, 20 PhD students and 6 post-docs. Our group is dedicated to:

- synthesis of isotopically-labeled organic molecules,
- synthesis of natural bioactive products
- functionalisation and use of carbon nanotubes
- supramolecular self-assemblies
- development of new tools for structural biology

Website: http://www-dsv.cea.fr/scbm

About the project: this project aims at developing a new spectroscopic methodology for observing the structure and dynamics of biological complex systems at work. The proof of concept has been demonstrated with the use of deuterium and tritium labeled small organic compounds. 3H NMR experiments will also be conducted in the frame of this project on bioactive compounds within their active site. Due to the innovative character of this project, publications in high IF journals (J. Am. Chem. Soc., Angew. Chem.) are expected.

About the candidate: A strong background in organic synthesis is required as are strong communication and interpersonal skills. He/she will extensively collaborate with the other teams involved in this project (biologists and NMR spectroscopists).

Contact: Dr. Jean-Christophe Cintrat; e-mail: ; Tel: + 33-1.69.08.25.70

Relevant publications:
An Isosparteine Derivative for Stereochemical Assignment of Stereogenic (Chiral) Methyl Groups Using Tritium NMR: Theory and Experiment
B.D. ALLEN, J.-C. CINTRAT, N. FAUCHER, P. BERTHAULT, B. ROUSSEAU, D.J. O’LEARY J. Am. Chem. Soc., 2005, 127, 412-420.

The Shortest Route to Chiral Ditosyl Methylamine
N. FAUCHER, J.-C. CINTRAT, P. BERTHAULT, B. ROUSSEAU Angew. Chem., Int. Ed. Engl., 2002, 41(3), 497-498.

Web: http://www-dsv.cea.fr/jccintrat